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Save Anavar and Tren for Cutting

Luxferro

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Anavar and Tren are two compounds which IMO should exclusively be used during a cutting phase.

This is because these are the only two AAS (as far as I’m aware) which antagonize the glucocorticoid receptor.

There are many things BESIDES testosterone which affect net muscle protein balance.

1) Androgen receptor activation upregulates muscle growth
2) Myostatin inhibits muscle growth
3) IGF-1/Insulin inhibits muscle breakdown/promotes anabolism
4) Glucocorticoid receptor activation by cortisol causes muscle breakdown


When you’re cutting, your body is going to release more cortisol than usual. Cortisol will bind to glucocorticoid receptors throughout the body including those on muscle tissue to induce catabolism.

Tren (and Anavar to a lesser extent), will compete for binding at these receptors. The result is greater lean body mass retention when cutting with these compounds.

I still don’t recommend Tren though for just about anyone. That shit is just way too toxic.
 

trenaholic

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Yep. Anavar usually enough to get the job done. Depending on where I start, I can usually cut to 10% or slightly less on TRT to cruise dose.

Below that bf%, with any sort of deficit that isn't grindingly slow, var becomes very important for me to maintain on a cut. Or even ink out a sliver of progress. Tren hasn't been necessary for me yet, as I'm still in the 8-10% range, but I wonder if it becomes a staple at 6-7 and below.

That said I plan on introducing tren to my cut tonight. Only 10mg a day, to replace some of the test I'm on. On 250mg test, I maintain a bunch of water, so wondering if trimming that out to 180mg test + 70mg tren will help me dry out a bit. Only plan to use a few weeks as I finish my cut. Plus, I'm out of var ;)

Side note there are other AAS that target the glutocorticoid receptor. But not as effective as the 2 you listed.
 

Luxferro

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Yep. Anavar usually enough to get the job done. Depending on where I start, I can usually cut to 10% or slightly less on TRT to cruise dose.

Below that bf%, with any sort of deficit that isn't grindingly slow, var becomes very important for me to maintain on a cut. Or even ink out a sliver of progress. Tren hasn't been necessary for me yet, as I'm still in the 8-10% range, but I wonder if it becomes a staple at 6-7 and below.

That said I plan on introducing tren to my cut tonight. Only 10mg a day, to replace some of the test I'm on. On 250mg test, I maintain a bunch of water, so wondering if trimming that out to 180mg test + 70mg tren will help me dry out a bit. Only plan to use a few weeks as I finish my cut. Plus, I'm out of var ;)

Side note there are other AAS that target the glutocorticoid receptor. But not as effective as the 2 you listed.
Buddy I wish you the best of luck with that. Me personally, I’m never going to touch Tren. Between transomnia, Tren cough, and the general toxicity of Tren relative to other AAS makes it a hard pass for me.

At least you’re using a low dose!

I wasn’t aware of other AAS antagonizing glucocorticoid receptors l. That’s pretty interesting I’ll have to look into it!

If I were in your shoes I’d personally keep test the same but add in primo or mast to fight water retention since those two will compete with T for binding to aromatase. End result will be a lower E2.

I really feel like the only scenario in which use of Tren is justified is if you’re about to step on stage and you’re in the last couple weeks of prep.
 

imagepb

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I’m in a Tren cycle. Dose is currently up to 400mg/ML. I have zero sides EXCEPT shortness of breath.

I was in a cut but shifted to a bulk with it. I actually didn’t get much out of it until late into the cycle! Finally started seeing results! But I also stacked Anavar into it!

Now I will say, my second cycle ever was my trt cycle from my doc of 250mg/ML and 60mg of pharma Anavar! I put on a good 10lbs of muscle that I kept, And cut down bf at the same time! My diet was setup for recomp with a slight surplus in calories. I loved that cycle.
 
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