Receptor site saturation Trt vs coming off

[johndoe24]

I see a lot of talk across boards and YouTube and stuff about how staying on year round will cause androgen receptors to downregulate and make the gear less effective.

I can see how blasting non stop would do this, but that’s the point of blasting and cruising.

Cruising on legit trt dose that puts you within the normal range to me would accomplish the same “clean out effect” as coming off and running pct. During pct your test is going to be low-normal, on trt your test will be mid-high normal. What’s a few hundred ng/dL diffference going to make in cleaning out the AR sites?

Thoughts and opinions on this?

 

[orical]

johndoe24" pid='27360' dateline='1538925663:

I see a lot of talk across boards and YouTube and stuff about how staying on year round will cause androgen receptors to downregulate and make the gear less effective.

I can see how blasting non stop would do this, but that’s the point of blasting and cruising.

Cruising on legit trt dose that puts you within the normal range to me would accomplish the same “clean out effect” as coming off and running pct. During pct your test is going to be low-normal, on trt your test will be mid-high normal. What’s a few hundred ng/dL diffference going to make in cleaning out the AR sites?

Thoughts and opinions on this?

You can cruise for a few months and then blast right after and your gear will be as effective as pct. It’s true that running gear year round will make you gain less, solution is to cruise or pct and your next cycle will do a lot more unless your very advanced.

Your trt dose should put you within normal test range or you’re no longer on trt but blasting.

 

[johndoe24]

When you say very advamced your talking about having to cruise on higher dose test in order not to lose muscle right?

 

[orical]

johndoe24" pid='27381' dateline='1538934460:

When you say very advamced your talking about having to cruise on higher dose test in order not to lose muscle right?

When I say very advanced, I mean you are atleast 5-10ibs heavier then your natural genetic limit. So without gear, your body won’t keep that muscle up so you will lose. Think a pro bb or a top end physique competitor. The moment those guys come off or lower their dose to low, they’ll deflate a little.

 

[solemnflipper17]

I thought that receptor down regulation was broscience and that there were studies showing high levels of androgens over a long period up regulated receptors

 

[flashpass123]

Androgen receptors do not down-regulate. Over time they actually up regulate. The whole purpose of cruising is to keep your health in check.

 

[FeatherGrain]

cruising helps spare the organs.

 

[juicyfatpowerlifter]

Androgen Receptors do not downregulate in vivo. Just like flashpass123 mentioned, if you have supraphysiological levels of AAS in your serum for a prolonged time, they will upregulate and your density of ARs will increase as well.

I would recommend the following excellent article that covers this in detail and depth, with a handy TLDR:

There is no scientific evidence whatsoever that AR downregulation occurs in human muscle, or in any tissue, in response to above normal (supraphysiological) levels of AAS.

Where AR downregulation in response to AAS has been seen in cell culture, these results do not apply because the downregulation is either not relative to normal androgen levels but to zero androgen, or estrogen may have been the causative factor, or assay methods inaccurate for this purpose were used, or often a combination of these problems make the results inapplicable to the issue of supraphysiological use of androgens by athletes.

AR upregulation in response to supraphysiological levels of androgen in cell culture has repeatedly been observed in experiments using accurate assay methods and devoid of the above problems.

AR downregulation in response to AAS does not agree with real world results obtained by bodybuilders, whereas upregulation does agree with real world results. (A neutral position, where levels in human muscle might be thought not to change in response to high levels of androgen, is not disproven however.)

The “theoretical” arguments advanced by proponents of AR downregulation are invariably without merit.

https://thinksteroids.com/articles/androgen-receptor-regulation/

But this doesn’t mean that it is wise to blast 365 days of the year, for health reasons, you should go on good long cruise on TRT Levels, get some bloodwork 6-8 weeks out, look at all the revelant markers, and see where you at.

 

[Xegar54]

I’m not going to B&C but I’m curious about the differences between blasting and cruising. From what I’ve read, a lot of people start to get more sides when they go down to a cruise than they do while on blast. Have you guys found the same thing happen to you? Do you guys taper down to a cruise or do you just wait a a couple weeks and start the cruise dose?

 

[Bearslovecheese]

Xegar54" pid='27477' dateline='1539032967:

I’m not going to B&C but I’m curious about the differences between blasting and cruising. From what I’ve read, a lot of people start to get more sides when they go down to a cruise than they do while on blast. Have you guys found the same thing happen to you? Do you guys taper down to a cruise or do you just wait a a couple weeks and start the cruise dose?

Tapering only prolongs getting to cruise dose. Just as we often double the first two pins in order to front load and get to blast levels, skipping injections for 1.5-2 weeks will rapidly drop you down to cruising levels of testosterone. So if you’re injecting twice a week, skip 3 full pints then next pin start cruise dose. Or skip 4 pins then start cruise dose. Punch it up on steroidcalc to see for yourself. Please note this is for longer esters (Enan/Cyp), short esters obviously clear faster (Ace 1.5x5 = 7.5 days, Prop 3x5 = 15 days) but you have to factor in adding in the longer esters on steroidcalc in this case.

 

[Xegar54]

Do you notice the rapid drop? Does it affect you in any way?

 

[flashpass123]

Xegar54" pid='27493' dateline='1539047944:

Do you notice the rapid drop? Does it affect you in any way?

When I drop my dose I lose a bit of muscle glycogen thats about it.

 

[knowstigma]

I am coming off a long cruise, its was tough for awhile, but I just fucking overdid it for too long. I needed a long break and for my body to normalize. My bloods never got bad, but I had too much shit going on and I just couldn’t focus.

Now, I just need to figure out what sources are still legit. Also, I am trying to do some research as it looks like there have been domestic busts? Those were kinda starting when I had to step away. Decided to come back with a new name and email address.