NGENLA (Somatrogon) long acting analog

[zoinks]

Hey all, has anyone tried NGENLA (Somatrogon) or any other long acting hgh analogs? Just doing some research on the topic and would love to hear any info or experience you may have on the topic.

Thanks for your time and info,
Zoinks

 

[CaptainAmerica]

I will actually be doing a full log on running this product here shortly. I have been researching for a a while and was able to calculate an IU ratio to get the dosing I wanted etc.

I’ll be going over methods, getting additional bloodwork like igf, serum, and glucose/insulin throughout.

From my research, this log may be the first for ngenla in the realm of bodybuilding. I was not able to find any blogs, anecdotes, etc except for Palumbo discussing it releasing and a more recent Chase Irons video in which he is completely incorrect with regard to its use and dosing.

 

[zoinks]

That is awesome to hear, I have been trying to gather info for myself but the topic is pretty scarce. Would you mind sharing the mL to IU ratio? When/where will you be posting this log?

 

[brutaltarik]

That is awesome to hear, I have been trying to gather info for myself but the topic is pretty scarce. Would you mind sharing the mL to IU ratio? When/where will you be posting this log?

I have read somewhere but can't remember now where that 1 24mg NGENLA pen is equal to roughly 28iu of HGH (4iu per day). @CaptainAmerica is that roughly what you work off of?

 

[AlexDavis43]

I have read somewhere but can't remember now where that 1 24mg NGENLA pen is equal to roughly 28iu of HGH (4iu per day). @CaptainAmerica is that roughly what you work off of?

That is similar to what I understand. Something like 60 mg/wk NGENLA = 10 IU hGH/d.

weekly NGENLA dose in mg / 6 = IU hGH/d

In your example, 24 mg / 6 = 4 IU/d.

Not sure if this is realistic or accurate.

 

[CaptainAmerica]

Hey @AlexDavis43, @brutaltarik, and @zoinks!

Sorry @zoinks this isn’t my thread so without a tag I didn’t see this.

We know from the studies that Pfizer was trying for an equivalent dosing and came to the numbers .24mg geno was equal to .66mg ngenla.

Math wise

.24/.24 =.66/.24
1 = 0.363

So to find your specific dose, me for example is 6iu/day. Which we know is 2mg (1mg is 3iu of daily gh) x 7 days = 14mg weekly

(1/0.363) x 14 =38.567

So my dosing is 38.5mg Ngenla per week.

Now knowing the long way, we can shorten to the fact that 1/0.363 is 2.75.

2.75x14=38.5

Therefore the conversion method is WEEKLY standard gh in MG (1mg:3iu) x 2.75 to reach your WEEKLY Ngenla dose.

Thank you for coming to my ted talk. FYI as far as I know I am the only person to have done the work on this. Everyone else I have seen says 1:3 as before which is incorrect. This information is copyrighted

I’ll be posting the log in SST likely in a new thread in this subforum and I’ll be starting it here at the beginning of October.

 

[dick_starbuck]

Hey @AlexDavis43, @brutaltarik, and @zoinks!

Sorry @zoinks this isn’t my thread so without a tag I didn’t see this.

We know from the studies that Pfizer was trying for an equivalent dosing and came to the numbers .24mg geno was equal to .66mg ngenla.

Math wise

.24/.24 =.66/.24
1 = 0.363

So to find your specific dose, me for example is 6iu/day. Which we know is 2mg (1mg is 3iu of daily gh) x 7 days = 14mg weekly

(1/0.363) x 14 =38.567

So my dosing is 38.5mg Ngenla per week.

Now knowing the long way, we can shorten to the fact that 1/0.363 is 2.75.

2.75x14=38.5

Therefore the conversion method is WEEKLY standard gh in MG (1mg:3iu) x 2.75 to reach your WEEKLY Ngenla dose.

Thank you for coming to my ted talk. FYI as far as I know I am the only person to have done the work on this. Everyone else I have seen says 1:3 as before which is incorrect. This information is copyrighted

I’ll be posting the log in SST likely in a new thread in this subforum and I’ll be starting it here at the beginning of October.

A sub forum for logs would be pretty cool. Just saying.

 

[AlexDavis43]

Hey @AlexDavis43, @brutaltarik, and @zoinks!

Sorry @zoinks this isn’t my thread so without a tag I didn’t see this.

We know from the studies that Pfizer was trying for an equivalent dosing and came to the numbers .24mg geno was equal to .66mg ngenla.

Math wise

.24/.24 =.66/.24
1 = 0.363

So to find your specific dose, me for example is 6iu/day. Which we know is 2mg (1mg is 3iu of daily gh) x 7 days = 14mg weekly

(1/0.363) x 14 =38.567

So my dosing is 38.5mg Ngenla per week.

Now knowing the long way, we can shorten to the fact that 1/0.363 is 2.75.

2.75x14=38.5

Therefore the conversion method is WEEKLY standard gh in MG (1mg:3iu) x 2.75 to reach your WEEKLY Ngenla dose.

Thank you for coming to my ted talk. FYI as far as I know I am the only person to have done the work on this. Everyone else I have seen says 1:3 as before which is incorrect. This information is copyrighted

I’ll be posting the log in SST likely in a new thread in this subforum and I’ll be starting it here at the beginning of October.

Oh, nice! Thanks. My calculation wasn't too far off. It would've put 38.5 mg/wk NGENLA as equivalent to 6.4 IU hGH/d.

 

[zoinks]

This is great information, Thank you guys!! Might place an order and see for my self. If I do, I will definitely keep some notes and share.

 

[zoinks]

@CaptainAmerica what source did you use to suply the NGENLA?

 

[CaptainAmerica]

@CaptainAmerica what source did you use to suply the NGENLA?

As a mod I would like to keep my own personal usage private just as a way to keep neutrality. Sorry man.

Back in the day we ran a poll about mods posting labs or bloods etc and it was decided the users did not want that swaying anyone.

 

[AlexDavis43]

As a mod I would like to keep my own personal usage private just as a way to keep neutrality. Sorry man.

Back in the day we ran a poll about mods posting labs or bloods etc and it was decided the users did not want that swaying anyone.

That's fair man. And anyway, not seeing many NGENLA fakes yet so a simple search could find the source of this product (pretty sure they're all getting it from the same place)

@CaptainAmerica what source did you use to suply the NGENLA?

 

[brutaltarik]

That's fair man. And anyway, not seeing many NGENLA fakes yet so a simple search could find the source of this product (pretty sure they're all getting it from the same place)

Probably not a popular enough product yet for it to be faked. How long was Ozempic on the market before fake pens started?

 

[readalot]

We know from the studies that Pfizer was trying for an equivalent dosing and came to the numbers .24mg geno was equal to .66mg ngenla.

Thanks for the writeup.

Efficacy and Safety of Weekly Somatrogon vs Daily Somatropin in Children With Growth Hormone Deficiency: A Phase 3 Study - PubMed

The efficacy of once-weekly somatrogon was noninferior to once-daily somatropin, with similar safety and tolerability profiles. (ClinicalTrials.gov no. NCT02968004).

pubmed.ncbi.nlm.nih.gov

Methods: In this 12-month, open-label, randomized, active-controlled, parallel-group, phase 3 study, participants were randomized 1:1 to receive once-weekly somatrogon (0.66 mg/kg/week) or once-daily somatropin (0.24 mg/kg/week) for 12 months. A total of 228 prepubertal children (boys aged 3-11 years, girls aged 3-10 years) with GHD, impaired height and height velocity (HV), and no prior rhGH treatment were randomized and 224 received ≥1 dose of study treatment (somatrogon: 109; somatropin: 115). The primary endpoint was annualized HV at month 12.

https://accp1.onlinelibrary.wiley.com/doi/10.1002/cpdd.1434

The study was conducted at a single center in the United States (QPS-MRA, LLC, South Miami, FL, USA) and included 49 healthy, adult, male participants. Signed informed consent was obtained from all participants prior to screening. The protocol and English and Spanish language versions of informed consent form were reviewed and approved by IntegReview IRB (Austin, TX, USA). The study was conducted in accordance with the US 21 Code of Federal Regulations, Parts 50, 56, and 312 and the principles enunciated in the Declaration of Helsinki and those found in the International Council of Harmonization guideline E6 (R2).

See Figs. 1 and 2.
12 mg somatrogon per week / 2.75 = 4.36 mg somatropin equivalent per week.

4.36 mg/week ÷ 7 days/week × 3 IU/mg = 1.87 IU/day equivalent of somatropin.

 

[AlexDavis43]

Thanks for the writeup.

Efficacy and Safety of Weekly Somatrogon vs Daily Somatropin in Children With Growth Hormone Deficiency: A Phase 3 Study - PubMed

The efficacy of once-weekly somatrogon was noninferior to once-daily somatropin, with similar safety and tolerability profiles. (ClinicalTrials.gov no. NCT02968004).

pubmed.ncbi.nlm.nih.gov

https://accp1.onlinelibrary.wiley.com/doi/10.1002/cpdd.1434

See Figs. 1 and 2.
12 mg somatrogon per week / 2.75 = 4.36 mg somatropin equivalent per week.

4 36 mg/week ÷ 7 days/week × 3 IU/mg = 1.87 IU/day equivalent of somatropin.

1 IU NGENLA is not equivalent to 1 IU hGH so I don't think the 3 IU/mg conversion applies but it's not far off. Could be wrong.

I calculated 66 mg/wk NGENLA = 10 IU hGH/d. So NGENLA works out to be a little more expensive than Genotropin. But much more convenient for dosing if it applies to bodybuilding like it does in kids with GHD etc

 

[readalot]

1 IU NGENLA is not equivalent to 1 IU hGH so I don't think the 3 IU/mg conversion applies but it's not far off. Could be wrong.

I only applied the IU/mg conversion factor (3) to the somatropin equivalent portion of the derivation.

For the somatrogon part, only worked in mg.

 

[AlexDavis43]

I only applied the IU/mg conversion factor (3) to the somatropin equivalent portion of the derivation.

For the somatrogon part, only worked in mg.

In that case our numbers (also Captain america) are very close. 66 mg NGENLA/wk equivalent to 10 IU hGH/d vs 10.285 hGH/d.

I've only seen one guy report IGF-1 levels on NGENLA but they didn't have IGF-1 on hGH to compare.

 

[readalot]

In that case our numbers (also Captain america) are very close. 66 mg NGENLA/wk equivalent to 10 IU hGH/d vs 10.285 hGH/d.

I've only seen one guy report IGF-1 levels on NGENLA but they didn't have IGF-1 on hGH to compare.

The variability among the participants in Fig. 1 and 2 (2024 paper linked above) seemed too good to believe. Incredibly tight.

 

[CaptainAmerica]

Hi everyone. Does anyone among you use the Ngenla pen? Dec. or are you just talking according to theoretical information on the Internet?

I’m running an entire log that’s stickied in this very subforum!

 

[Jfrost89]

I got 2 60mg pins to try.

I’m currently on 10iu a day of gh but I plan on running the Ngenla a bit different than most. I’m a driver engineer and paramedic at the FD so I work every 3rd day.

I plan to run 10iu on trading days, 5iu on non training days (generics)

Each pin is 60mg (180iu) / 1.2ml but Chase irons says you can stick a slin pin in and draw out an additional 0.3ml if that’s the case there should be 225iu/1.5ml so I plan to split it by 10 doses and do 15iu on a slin pin e3d which should be 22.5iu.

So it’ll be 10iu of generics on training days, 5iu of generics with 22.5iu of Ngenla on non training days e3d.

I train 2 on 1 off so 122.5iu a week of gh. Either I’m going to put on some size or grow size 18 feet not sure yet but we’re going to find out