Not to hijack the thread from the OP, but my TT trough is 992ng/dL on 200mg/wk. FT is 25.6, just hardly within range on the high side and maybe SHBG is 5.8, extremely low.Your FT is high because your SHBG is low.
This will cause your estradiol to be higher than what most would expect it to be, when considering your TT value.
Hmm, this is peculiar for sure. With an SHBG this low, your FT shouldn’t be so normal.FixerUpper" pid='24574' dateline='1536085189:
Not to hijack the thread from the OP, but my TT trough is 992ng/dL on 200mg/wk. FT is 25.6, just hardly within range on the high side and maybe SHBG is 5.8, extremely low.Your FT is high because your SHBG is low.
This will cause your estradiol to be higher than what most would expect it to be, when considering your TT value.
Is there a clinical problem with these measurements?
I haven’t found a clear explanation for how to deal with low SHBG or if it’s even a problem to begin with
^^ this.PissedPajamas" pid='24576' dateline='1536086477:
Hmm, this is peculiar for sure. With an SHBG this low, your FT shouldn’t be so normal.FixerUpper" pid='24574' dateline='1536085189:
Not to hijack the thread from the OP, but my TT trough is 992ng/dL on 200mg/wk. FT is 25.6, just hardly within range on the high side and maybe SHBG is 5.8, extremely low.Your FT is high because your SHBG is low.
This will cause your estradiol to be higher than what most would expect it to be, when considering your TT value.
Is there a clinical problem with these measurements?
I haven’t found a clear explanation for how to deal with low SHBG or if it’s even a problem to begin with
What was your albumin level on your last set of bloodwork? If albumin is high, that could cause a result like this. It would likely need to be REALLY high though, which you don’t see too often.
Have you seen SHBG results like this consistently? There’s always the possibility of a lab error, but you can rule that out if your SHBG has been this low on multiple blood tests.
It seems likely that your SHBG was already on the low end, but has been driven lower by your steroid use. Androgens lower SHBG in a dose dependent fashion. It is common for SHBG to go WAY down in somebody who uses AAS…this is pretty extreme though. Your SHBG was likely already fairly low to begin with.
Fixing low SHBG isn’t that easy though, and it’s something that many guys on TRT struggle with. For one reason or another, men with low SHBG seem to have a difficult time reaping the benefits of TRT. SERMs will increase SHBG, but most don’t like the idea of using a SERM in this situation.
The effects of low SHBG are just now being discovered in medicine. There is a STRONG connection between low SHBG and metabolic syndrome, insulin resistance, thyroid dysfunction, arterial calcification, elevated C-reactive protein…the list goes on.
As you can see, it’s a pretty complicated issue.
PissedPajamas" pid='24576' dateline='1536086477:
Weird, I feel pretty great on TRT with twice a week injections. I guess this is an “if it ain’t broke don’t fix it” issue?FixerUpper" pid='24574' dateline='1536085189:
Not to hijack the thread from the OP, but my TT trough is 992ng/dL on 200mg/wk. FT is 25.6, just hardly within range on the high side and maybe SHBG is 5.8, extremely low.Your FT is high because your SHBG is low.
This will cause your estradiol to be higher than what most would expect it to be, when considering your TT value.
Is there a clinical problem with these measurements?
I haven’t found a clear explanation for how to deal with low SHBG or if it’s even a problem to begin with
Hmm, this is peculiar for sure. With an SHBG this low, your FT shouldn’t be so normal.
What was your albumin level on your last set of bloodwork? If albumin is high, that could cause a result like this. It would likely need to be REALLY high though, which you don’t see too often.
Have you seen SHBG results like this consistently? There’s always the possibility of a lab error, but you can rule that out if your SHBG has been this low on multiple blood tests.
It seems likely that your SHBG was already on the low end, but has been driven lower by your steroid use. Androgens lower SHBG in a dose dependent fashion. It is common for SHBG to go WAY down in somebody who uses AAS…this is pretty extreme though. Your SHBG was likely already fairly low to begin with.
Fixing low SHBG isn’t that easy though, and it’s something that many guys on TRT struggle with. For one reason or another, men with low SHBG seem to have a difficult time reaping the benefits of TRT. SERMs will increase SHBG, but most don’t like the idea of using a SERM in this situation.
The effects of low SHBG are just now being discovered in medicine. There is a STRONG connection between low SHBG and metabolic syndrome, insulin resistance, thyroid dysfunction, arterial calcification, elevated C-reactive protein…the list goes on.
As you can see, it’s a pretty complicated issue.