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Difference between pharma hgh and generic

methyl mike

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Testing for hGH concentration matters, but other ingredients in the final product may also have an effect.

For example, I read that some pharma hGH has diuretics added to help manage water retention. UGL hGH might have the same exact amount of hGH, but not other ingredients that influence side effects, bioavailability, efficacy, etc.

*for what it's worth, I've used both and didn't notice a difference, so I stick with UGL because of the price difference
Excellent post
 

kits4less

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Some people swear that pharmaceutical HGH gives them less side effects. The only possible somewhat reasonable explanation I've heard that could explain that is dimer count, however even the science surrounding that is pretty swirly at best.

That being said, even if its not the scientific method, I don't think you can discount anecdote. If someone swears they get less water retention with pharm, then it's tough to argue with that.
By that same token, the cost per IU difference between generics and pharm is so staggering, that you really need to have deep pockets to justify it IMO. Or very competitive goals/aspirations.

Secondarily, I guess legality is also on some people's hierarchy of importance. If you can get a script for GH, some people would much rather do that then go through the hassle of sourcing on the underground.

A tertiary consideration is well, HGH pens are cool and convenient as hell. Trying to draw out that last drop of GH from a vial of generics can be a PITA.
 

methyl mike

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Well speaking from personal experience with years of both pharma growth US Nutropin and Phizer Geno pens and then the great all consistently tested Opti, TP , QSC and more all showing near or the same or sometimes even higher purity than pharma this “bro science” “folklore” tale has been squashed for a while now. And to solidify testing all these places have also been third party blind tested as well and still show same great results. Is the purity with a very small % of pharma more consistent with a tad higher purity …sure. But it’s miniscule and this question will always be asked once in a blue moon from a newbie and you’ll always get the couple people who only praise pharma . That’s good your entitled to your opinion. But I can also tell you my oils come out always correctly dosed and no impurities either but you will never see me paying pharma prices for Var or US test when I get it for 1/4 the price and it’s smoother exact same Purity and actually properly priced and not big pharma rip off prices
You have ran nutropin? When was this and what did it cost?

The rest of your post is not wrong however I would like to point something out for you to consider.

It is true that HPLC testing has consistently shown very small differences in purity between one ugl or another and pharma brand a b or c.
You made a statement that the difference in purity is "miniscule" and on paper jt is. Or at least should be. 94.7% vs 93.9% vs 96.2% etc etc etc. I would definitely assume you could take any other those GH batches and not be able to.notice any difference whatsoever. But I think there is actually a difference.

For example I'm usually loyal to opti greys. Very effective, straight away I see my abs start to look slightly better, my body overall starts looking leaner very fast. I can handle 2-4 ius a day if I use more I always regret it. Cts and water retention like crazy. It's legit potent.


Currently I'm running his orange tops. I figure logically they are half the cost and there must be a reason so I am running a fair but higher, around 10 ius a day +/- 2 or 3

The orange tops tested very well, but even at a higher dose the effect on my body just is not the same. Orange tops are definitely real HGH and I do believe they are accurately consistently filled, but they just aren't quite as effective as greys. I do not believe I can get the same effect by using more either. It's like I'm driving a sporty Mazda trying to keep up with a ferrari. I could have 100 Mazdas and none of them will be able to catch or beat the ferrari. A thousand Mazdas again none of them would beat it.

I think that analogy works pretty good. And this seems to agree with anecdotal data as well. Guys who have used pharma usually all say pharma is just a bit better. More fat loss faster body comp changes less sides etc. No one ever says pharma GH just obliterates UGL and they aren't comparable. Generic GH definitely works if it didn't no one would buy it. But there is a difference. How much money does that difference cost and is it worth it is up to the individual.

My .02_
 

holdentudix

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Some people swear that pharmaceutical HGH gives them less side effects. The only possible somewhat reasonable explanation I've heard that could explain that is dimer count, however even the science surrounding that is pretty swirly at best.

That being said, even if its not the scientific method, I don't think you can discount anecdote. If someone swears they get less water retention with pharm, then it's tough to argue with that.
By that same token, the cost per IU difference between generics and pharm is so staggering, that you really need to have deep pockets to justify it IMO. Or very competitive goals/aspirations.

Secondarily, I guess legality is also on some people's hierarchy of importance. If you can get a script for GH, some people would much rather do that then go through the hassle of sourcing on the underground.

A tertiary consideration is well, HGH pens are cool and convenient as hell. Trying to draw out that last drop of GH from a vial of generics can be a PITA.
Worth noting that generics can be found in cartridges. There's also a refillable injector thread on meso for diy purposes.
 

Primoisthebest

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It’s probably reasonable to expect human nature plays a role in noted effects. Guy pays top dollar for pharma gh and is that much more dialed in on training and esp diet. That vs generic where price is so cheap it’s just thrown in when diet may be looser so mor bloofy result.
 

MuscleMongoose

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Did you all ever watch that video of the guy who explains the difference?

He said get your favorite generic brand. Run two bottles worth and note how you feel.

Then take 8 weeks off? Maybe 16? I forget.

Then when you’re ready to start back up he said get real pharma hgh and start using that and within just one week on pharma hgh you’ll know the difference.

He could just be speaking out his ass but he was a pro and used lots of it.

I need to find the link if I can still find it.
 

dick_starbuck

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One LARGE difference between pharma HGH and generic is the content of the product. If you read the ingredient list for genotropin it contains mannitol, which is a medication used as a diuretic. The reason some pharma gives less edema is that it contains a diuretic.

I recently asked Broderick Chavez what difference he noticed between quality generics and pharma. He stated that the dimer content was likely the reason for the difference in perceived side effects and benefits.
 

1a6rnner

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One LARGE difference between pharma HGH and generic is the content of the product. If you read the ingredient list for genotropin it contains mannitol, which is a medication used as a diuretic. The reason some pharma gives less edema is that it contains a diuretic.

I recently asked Broderick Chavez what difference he noticed between quality generics and pharma. He stated that the dimer content was likely the reason for the difference in perceived side effects and benefits.
I'm showing my ignorance here, dimer content does what exactly?
 

dick_starbuck

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I'm showing my ignorance here, dimer content does what exactly?
I'm going to keep it 💯 here... I don't 100% know haha. When I asked him to explain the connection he said no, and to pay for the Team Evil GSP membership because the information is there. Which I intend to do EVENTUALLY but have not gotten to yet.
 

Arbiter

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I'm showing my ignorance here, dimer content does what exactly?
No one really knows. Some used to suggest that more dimer meant more water retention and CTS but Janoshik's new testing method is finding dimer in almost all samples from suppliers that used to have none at all. Maybe not the case that dimer actually causes any issue or side effect at all.
 

dick_starbuck

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No one really knows. Some used to suggest that more dimer meant more water retention and CTS but Janoshik's new testing method is finding dimer in almost all samples from suppliers that used to have none at all. Maybe not the case that dimer actually causes any issue or side effect at all.
I actually found out what it was since I posted in this thread previously.

Per Broderick Chavez, it's when the 191aa HGH is in the right ORDER (it is HGH) sequence of amino acids. But it's bonded incorrectly and "tangled together" as he put it. Why does this cause side effects? Not known. My best theory would be that it interacts on aldosterone and mineralocorticoid receptors in a different way than regular HGH. It's likely due to poor quality control during manufacture.
 

AlexDavis43

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I actually found out what it was since I posted in this thread previously.

Per Broderick Chavez, it's when the 191aa HGH is in the right ORDER (it is HGH) sequence of amino acids. But it's bonded incorrectly and "tangled together" as he put it. Why does this cause side effects? Not known. My best theory would be that it interacts on aldosterone and mineralocorticoid receptors in a different way than regular HGH. It's likely due to poor quality control during manufacture.

@Janoshik and a few others have commented that we're all guessing, but most people guess the same thing: higher dimer = more side effects. (other people say excipients and other additives but that's a different topic)

As @Arbiter suggested, might have something to do with differential effects of GH dimer vs. GH on some GH targets but not all.

For example, maybe GH dimer has more GH receptor activity in certain tissues but less in others for other reasons. No one knows the reason, but we can all make guesses based on hints or observations.
 

PCTAccount

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Well, it depends how it was synthesized. From what, how it was stored, and how it's actually processed in the body using what specific peptide sequencing technology. There's a LOT of information channels to process with "HGH" (HGA, HGD, HGPHD) and different "amino counting moves" i.e. so on and so forth. It's an extremely sophisticated technology.


The difference is not really clearly measurable. With a cheap kit you could be getting pretty much anything. It could work great by natural development or end up being some quick bloat effect. As long as it's real it works. You could also be buying from a dirty source in bulk and having other people pay the price.... Lol ..

With pharmacy quality HGH? You get a sophisticated channel of sequencing efforts that could be utilizing a LOT of different technologies. Even by that metric being deducted, the natural development of a quality extracted and grown HGH peptide is going to be of extreme quality. It's the stuff that gives you the fullness, the roundness, the water moving in just right and staying out of the skin. That shrink wrapped effect of localized growth where YOU want it and paid for it be. Think a team of scientists following you with stealth laser technology and Magento boards to pull and shape and mutate your body in the best designer effort imaginable. That's real HGH.
 

PCTAccount

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Well, it depends how it was synthesized. From what, how it was stored, and how it's actually processed in the body using what specific peptide sequencing technology. There's a LOT of information channels to process with "HGH" (HGA, HGD, HGPHD) and different "amino counting moves" i.e. so on and so forth. It's an extremely sophisticated technology.


The difference is not really clearly measurable. With a cheap kit you could be getting pretty much anything. It could work great by natural development or end up being some quick bloat effect. As long as it's real it works. You could also be buying from a dirty source in bulk and having other people pay the price.... Lol ..

With pharmacy quality HGH? You get a sophisticated channel of sequencing efforts that could be utilizing a LOT of different technologies. Even by that metric being deducted, the natural development of a quality extracted and grown HGH peptide is going to be of extreme quality. It's the stuff that gives you the fullness, the roundness, the water moving in just right and staying out of the skin. That shrink wrapped effect of localized growth where YOU want it and paid for it be. Think a team of scientists following you with stealth laser technology and Magento boards to pull and shape and mutate your body in the best designer effort imaginable. That's real HGH.
Don't forget about the elite military technology crew and their slick click remotes that blank you out for stealth microcannualae PRP and liposuction. That's IFBB HGH.
 

beast405

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L
You just answered the question and validated what I said so thank you. The question was is there a difference? The answer is YES there's a difference. Nobody said anything about there being anything wrong with Generic GH. I'm not one of those Pharm only people my friend I love me some QUALITY generic any day of the week. In fact I have several kits of Opti just waiting to be run, and I'm looking forward to seeing the results (in about 3-6 months of course). With that being said let me ask you this, and then I'm done talking about the "differences".......If Generic GH is on the same level playing field as Pharm Grade then why in the world do the top bodybuilders who compete for a living spend tens of thousands of dollars on their GH?? Why not just put an order in with any number of quality generic sellers, and load up, and save thousands and thousands of dollars?? The answer is simple, and you yourself already answered it - It's because there's a difference...End of Story

As far as testing gear goes I've got test results right here from my imaginary lab that say my Cottonseed oil is actually Test E dosed at 242mg per ML with zero impurities. It has a nice stamp on it too with a squiggly signature so looks all legit. We're Having a big buy 1 get 1 free sale this weekend too with free shipping so step right up.....My cheerleaders will be posting away talking about the great results they're seeing on my garbage, Oh I'm sorry I mean my stuff. Don't worry we're third party tested too.....See where I'm going here?? Give me a break on all of that we're tested stuff it's nauseating. The only testing I care about, and trust, comes from Bloodwork posted up by actual end users that have just spent their hard earned coin on their gear. I care about my fellow gym rat brothers and sisters who get scammed on a daily basis by these losers who are setting up shop, and then grabbing their cash, and closing down, and then reopening a few months later under a new name. They claim to the ends of the earth their stuff is third party tested blah blah blah....I'm not interested in the sales pitch, and I don't really give a crap if the vial has a cute label on it. As long as it has the appropriate amount of the correct gear that's dosed reasonably close, and I'm not hobbled, or worse, for two weeks after injecting then it's all good. When guys claim to be running 500mg of Test a week, and for the sake of argument they're in good health with no other issues, and their labs come back at 1,000 for total T then Houston we have a problem!! but we can't be having that problem cuz their stuff has been tested right? See where I'm going with that....No thanks keep your testing just give me what I paid for......NOT RIPPING YOU BRO JUST MAKING MY FEELINGS KNOWN ABOUT TESTING!!......Stay Safe
My man there are and have been several pros and top national level guys who only run generics and that’s a fact ! 1000%. Not everyone making money from bodybuilding can afford to buy pharma grade gh when generics provide just as good of results for a fraction of the cost. On top of that majority of pharma grade on the market is counterfeit
 
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methyl mike

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Tldr. Were asking what the difference is between the two. Labtests done on pharm grade show <100% potency and dimer just like generics can. So what's the difference?
Pro bodybuilders run GH at very high dosages, the sides from generics would cripple them. Also you don't want to IV generic GH it doesn't have a preservative to keep it sterile. The differences between pharma and generic are side effects and potency, both of which are proportional to how much the GH has degraded. If there was a generic that had a preservative added as well as being manufactured stored and shipped in sterile climate controlled environments it would basically be pharma and would cost the same. Also HPLC cannot tell if the product sat in the sun for a week before being shipped. I trust bloodwork from end users and their anecdotal data personally but nothing is ever fool proof.
 

parksisme

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Pro bodybuilders run GH at very high dosages, the sides from generics would cripple them. Also you don't want to IV generic GH it doesn't have a preservative to keep it sterile. The differences between pharma and generic are side effects and potency, both of which are proportional to how much the GH has degraded. If there was a generic that had a preservative added as well as being manufactured stored and shipped in sterile climate controlled environments it would basically be pharma and would cost the same. Also HPLC cannot tell if the product sat in the sun for a week before being shipped. I trust bloodwork from end users and their anecdotal data personally but nothing is ever fool proof.
I am running 4 iu and now on 3rd month at that dose and I feel crippled. It has all my joints stiff. If I could afford pharma I would compare. But for me this may be my 1st and last experiment with hgh
 
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