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Semaglutide (Ozempic) - The Holy Grail Of Fat Loss?

Initially approved by the FDA back in 2017 for controlling type II diabetes in adults, semaglutide is a drug that belongs to the group of the GLP-1 (glucagon-like peptide 1) analogues. This group of substances has the ability to mimic the body's response after eating a meal, including feeling full, as well as regulating insulin response and altering gastric emptying. Before that, liraglutide, another GLP-1 analogue, had been approved by the FDA in 2010 under the brand name Saxenda.

Clinical studies involving semaglutide showed that patients on it were also losing weight, somewhere in the neighborhood of 11lbs over the course of three months. While that may not seem like much, this loss in body weight came with no dietary modifications, so take a moment and just imagine how powerful this drug can be if paired with a moderately aggressive caloric deficit.

As a matter of fact, users have reported losing 15 up to 20% of total bodyweight in that same timeframe when taken in conjunction with proper dieting and training. That's huge! If we take a 200lbs individual, we're talking about some 30lbs of weight (mostly fat, if the other variables are optimal) lost in three months.

Naturally, as this new drug hit the market under the brand names Ozempic and Wegovy, both from the Danish pharmaceutical company Novo Nordisk, we are seeing a tremendous interest in it coming from bodybuilders, fitness fanatics, soccer moms and just about anybody looking to lose weight. Ozempic is originally meant for type II diabetes control, while Wegovy was formulated more specifically for its weight loss capabilities.

Individuals taking semaglutide (or other GLP-1 analogues for that matter) can expect the following benefits:

- Once-a-week subcutaneous application;
- Loss of appetite;
- Controlled insulin levels even with higher glycemic loads;
- Easier to stay on diet;
- Especially helpful for overweight or obese individuals;
- Slower gastric emptying (feel full for longer).

We all know there's no free lunch, so you can expect as possible side effects:

- Moderate Nausea, vomiting, constipation, diarrhea and abdominal discomfort;
- Liver issues if individual is prone to it;
- Prolonged use may cause pancreas amylase levels to rise;
- Drug withdrawal has to be done slowly and gradually;
- May cause hypoglycemia since you won't feel the need to eat as often;
- Aggressive rebound, meaning if you go back to eating as you did before you'll most likely gain the weight back;

Personally, the way I see these GLP-1 drugs is as a tool to help you adhere to a better diet and lose fat, especially if you are overweight or obese. Its use should be limited to a certain period of time, paired with proper dieting and training, and discontinued as you reach a better physique, not as something that allows you to eat whatever. As such, it's very powerful and can yield amazing results.

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Where is admin?
It is about advertisement on your website.
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Still not sure if you're talking about our site, but you're welcome to open a ticket here:

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Customer Support and Customer Success Departments at Steroidify.com

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Hi friends.

Our site has been under unusually heavy ddos attack since Sunday afternoon and all protection systems kick in to keep site up.
But the attackers often use IPs from areas where most people order from, especially within the US.
This causes our cloud service to automatically ban some of these IPs.

So, if you're having problems to access our site, please clean cookies, use a different browser and/or change country on your VPN.

This should work for most cases. If you're still having problems, please let me know your email address registered on our site privately and I can pass the info to our tech team and they can manually give you access.

Sorry for the inconvenience. Should be back to 100% in next few hours or maybe couple of days.

The Steroidify Team.

 

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Ursolic Acid - The perfect supplement?

Ursolic acid is a pentacyclic triterpenoid first identified in apple waxes as early as 1920, but can also be found in the peels of many fruits, as well as in herbs and spices like rosemary, basil, oregano and thyme. It's more commonly used today in cosmetic products due to its ability to improve the appearance of wrinkles and age spots by restoring the skin's collagen structures and its elasticity.

As we've seen, Ursolic acid is not a new compound. In fact, there are studies dating back to the 1940s. Its properties regarding the cosmetic features and its ability to promote apoptosis (the death of certain cancer cells) have been established at this point, but what we're really interested in is its potential as a bodybuilding supplement.

Possibly, the first study we should look at was published in 2011, in which researchers used a "connectivity map" to search for compounds with anti-catabolic properties. More than 1300 compounds were tested and Ursolic acid rose to the top as a powerful inhibitor of the genes associated with muscle atrophy. Following this, several other studies (done with mice), have shown that Ursolic acid is not only capable of preventing catabolism under stressful situations (i.e., fasting), but it is also capable of increasing muscle mass and alter the proportion between brown and white fat deposits in the body while reducing overall fatness. As we know, brown fat cells are more easily oxidized and converted into usable energy by the body.

A quick resume of these results can be seen in the image below:

To summarize the benefits of supplementing with Ursolic acid, we put together the following list:

- Decreases markers of skeletal muscle damage during resistance training, thus reducing training-induced muscle tissue breakdown;
- Reduced catabolism even under stressful situations;
- Positive effects on individuals with metabolic syndrome;
- Improved insulin sensitivity;
- Decreased inflammation;
- Increased muscle mass and strength (when compared to weight-training alone);
- Higher rates of non-shivering thermogenesis (utilization of fats for fueling the body);
- Improved levels of irisin in blood (higher levels of irisin makes fat cells more thermogenic);
- Extended the activity of signaling pathways, including mTORC1 for a longer period of time (up to 6 hours after resistance training, where the control group had already fallen to baseline level);
- Decreased diet-induced obesity, glucose intolerance and fatty liver disease;
- Growth inhibition of some types of cancer cells.

Although the human trials are lacking, the typical dose seems to be 150mg three times a day, together with larger meals. Here we can observe perhaps what is keeping Ursolic acid from reaching its enormous supplement potential: the poor bioavailability. It's estimated that only about 1% of a dose is actually absorbed.
Efforts are being made right now to improve its bioavailability, with possible solutions including the use of cyclodextrins and reducing the particles to nanometers in size. Unfortunately, neither of these technologies is viable at the moment for the supplementation industry. Another possible solution is to utilize its transdermal form, but there's also a high cost associated with that and its effectiveness is yet to be proven.

For now, the options available for those willing to try this supplement are the pharma products available Ursacol by Zambon, Ursofalk by Falk Pharma, among others or by buying it in bulk, assuming you have a trusted supplier.

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For more articles like this, please visit our blog:

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Where is admin?
It is about advertisement on your website.
Thank.

Hello, friend.

I'm afraid I don't really understand what you're trying to say.
There's no advertisement on our website, but you're more than welcome to send us a message using the link below:

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Customer Support and Customer Success Departments at Steroidify.com

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Thanks.

 

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Hi friends.

Our site has been under unusually heavy ddos attack since Sunday afternoon and all protection systems kick in to keep site up.
But the attackers often use IPs from areas where most people order from, especially within the US.
This causes our cloud service to automatically ban some of these IPs.

So, if you're having problems to access our site, please clean cookies, use a different browser and/or change country on your VPN.

This should work for most cases. If you're still having problems, please let me know your email address registered on our site privately and I can pass the info to our tech team and they can manually give you access.

Sorry for the inconvenience. Should be back to 100% in next few hours or maybe couple of days.

The Steroidify Team.

Hello again, guys.

Still not 100%.
Most people are being able to access with TOR browser, so please try it if our site is not loading up properly on your current browser.

Thank you.

 

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