FWIW I have no real contribution regarding
@JG91's input on dosing schedule. I have seen some comments alluding to why it potentially may not be ideal to to dose more frequently than prescribed, but I find twice weekly for Reta works very well for me. By day 5 or 6 the food noise comes back a bit. Its possible that just increasing my dose could prevent this (4mg once at the start of the week vs. 2mg on Monday and then feeling a bit of food noise by Saturday) but twice weekly has worked really well for me so far and I'm still only on 4mg per week coming up on low double digit bf.
Nothing crazy but getting lean-lean for me is a challenge. Whether I don't have the willpower other people have or I lack the genetic advantage to shed fat more effortlessly, reta has been a gamechanger for me in not having to prohibit some foods from even being in the house. I don't care about them. I could eat them if I really wanted but they don't scream at me to be eaten.